The pharmacokinetic-nephrotoxicity relationships of CMS and CMS-E2 from the perspective of plasma and kidney drug concentrations in rats

Abstract Nephrotoxicity has seriously affected the clinical application of colistin methanesulphonate (CMS). Colistin B methanesulphonate (CMS-E2) is a novel polymyxin developed and aimed to have lower nephrotoxicity. This study aimed to investigate the relationships between pharmacokinetics (PK) an...

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Principais autores:	Chenxue Guo, Lin Xi, Xingyi Qu, Zhiwei Huang, Size Li, Wanzhen Li, Xiaofen Liu, Jing Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-05-01
Colecção:	Scientific Reports
Assuntos:	Colistin Colistin methanesulphonate (CMS) Colistin B Polymyxins Pharmacokinetic-toxicodynamic Nephrotoxicity
Acesso em linha:	https://doi.org/10.1038/s41598-025-96407-7
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