Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells

Summary: The pancreatic hormone, glucagon, is known to regulate hepatic glucose production, but recent studies suggest that its regulation of hepatic amino metabolism is equally important. Here, we show that chronic glucagon receptor activation with a long-acting glucagon analog increases amino acid...

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Principais autores:	Emilie Elmelund, Katrine D. Galsgaard, Christian D. Johansen, Samuel A.J. Trammell, Anna B. Bomholt, Marie Winther-Sørensen, Jenna E. Hunt, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Trisha J. Grevengoed, Jens J. Holst, Nicolai J. Wewer Albrechtsen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-11-01
coleção:	iScience
Assuntos:	Biological sciences Endocrinology Transcriptomics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004222015681
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