Dose-dependent effects of Metformin on proliferation and odontogenic differentiation of dental pulp stem cells

Abstract Background Metformin has emerged as a potential bioactive agent in regenerative medicine; however, its optimal concentration for enhancing dental pulp stem cell (DPSC) function remains unclear. This study evaluated the dose-dependent effects of Metformin (500 µM and 1000 µM) on DPSC prolife...

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Principais autores:	Rania Rashad Omar Omar Taha, Nashwa El-Khazragy, Shereen Hafez Ibrahim, Nermine Hassan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	BMC Oral Health
Assuntos:	Dental pulp stem cells (DPSCs) Metformin Odontogenic differentiation Alkaline phosphatase (ALP) Regenerative endodontics
Acesso em linha:	https://doi.org/10.1186/s12903-026-08221-w
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