Enhancing T cell anti-tumor efficacy with a PD1-TIGIT chimeric immune-checkpoint switch receptor

Chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated success in the treatment of hematological malignancies; however, its efficacy and applications in solid tumors remain limited. Immunosuppressive factors, particularly inhibitory checkpoint molecules, restrict CAR T cell activity i...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Jingjing Zhao, Jiebin Dong, Changwen Deng, Qianjing Zhang, Shicheng Sun, Honggang Li, Yun Bai, Hongkui Deng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2023-12-01
coleção:	OncoImmunology
Assuntos:	Cancer immunotherapy chimeric antigen receptor T immune-checkpoint PD1 TIGIT
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/2162402X.2023.2265703
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!