The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models

Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and accumulation of alpha-synuclein (aSyn). To enable a bette...

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Autors principals:	Nicole K. Polinski, Terina N. Martinez, Sylvie Ramboz, Michael Sasner, Mark Herberth, Robert Switzer, Syed O. Ahmad, Lee J. Pelligrino, Sean W. Clark, Jacob N. Marcus, Sean M. Smith, Kuldip D. Dave, Mark A. Frasier
Format:	Artigo
Idioma:	Inglês
Publicat:	The Company of Biologists 2022-06-01
Col·lecció:	Disease Models & Mechanisms
Matèries:	gcase alpha-synuclein parkinson's disease
Accés en línia:	http://dmm.biologists.org/content/15/6/dmm049192
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