Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression

Abstract Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously showed that miR-100 and miR-125b, embedded within the third intron of the ncRNA host gene MIR100HG, confer resistanc...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Hao Liu, Danxiu Li, Lina Sun, Hongqiang Qin, Ahui Fan, Lingnan Meng, Ramona Graves-Deal, Sarah E. Glass, Jeffrey L. Franklin, Qi Liu, Jing Wang, Timothy J. Yeatman, Hao Guo, Hong Zong, Shuilin Jin, Zhiyu Chen, Ting Deng, Ying Fang, Cunxi Li, John Karijolich, James G. Patton, Xin Wang, Yongzhan Nie, Daiming Fan, Robert J. Coffey, Xiaodi Zhao, Yuanyuan Lu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-03-01
coleção:	Molecular Cancer
Assuntos:	MIR100HG hnRNPA2B1 TCF7L2 N6-methyladenosine (m6A) Wnt/β-catenin signaling EMT
Acesso em linha:	https://doi.org/10.1186/s12943-022-01555-3
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!