Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs

Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by loss of Purkinje cells in the cerebellum. SCA6 is caused by CAG trinucleotide repeat expansion in CACNA1A, which encodes Cav2.1, α1A subunit of P/Q-type calcium channel. However, the pathogenic...

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Autors principals:	Yoshihito Ishida, Hideshi Kawakami, Hiroyuki Kitajima, Ayaka Nishiyama, Yoshiki Sasai, Haruhisa Inoue, Keiko Muguruma
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2016-11-01
Col·lecció:	Cell Reports
Matèries:	spinocerebellar ataxia type 6 SCA6 Purkinje cell induced pluripotent stem cells iPSCs disease modeling
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124716314292
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