Synovial sarcoma reprograms transcription by GBAF activation of polycomb targets and loss of CBAF enhancers

Abstract Synovial sarcoma is a cancer driven by a fusion oncoprotein, SS18::SSX, that links SS18, a subunit of BAF-family chromatin remodeling complexes, to the carboxy terminus of SSX, which avidly binds nucleosomes with the histone post-translational modification H2AK119ub. Here, we show in mice t...

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Egile Nagusiak:	Jinxiu Li, Li Li, Kyllie Smith-Fry, Muhammad Zaki Fadlullah, Lara Carroll, Linda Morrison, Xinyi Ge, Mary L. Nelson, Lesley A. Hill, Yixuan Guo, George Davenport, Xiaoyang Zhang, Torsten O. Nielsen, Martin Hirst, T. Michael Underhill, Bradley R. Cairns, Kevin B. Jones
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Nature Portfolio 2025-12-01
Saila:	Nature Communications
Sarrera elektronikoa:	https://doi.org/10.1038/s41467-025-67841-y
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