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Enolase Inhibitors as Early Lead Therapeutics against <i>Trypanosoma brucei</i>

Glucose metabolism is critical for the African trypanosome, <i>Trypanosoma brucei</i>, serving as the lone source of ATP production for the bloodstream form (BSF) parasite in the glucose-rich environment of the host blood. Recently, phosphonate inhibitors of human enolase (ENO), the enzyme responsib...

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Auteurs principaux: Colm P. Roster, Danielle LaVigne, Jillian E. Milanes, Emily Knight, Heidi D. Anderson, Sabrina Pizarro, Elijah M. Harding, Meredith T. Morris, Victoria C. Yan, Cong-Dat Pham, Florian Muller, Samuel Kwain, Kerrick C. Rees, Brian Dominy, Daniel C. Whitehead, Md Nasir Uddin, Steven W. Millward, James C. Morris
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2023-10-01
Collection:Pathogens
Sujets:
enolase
African trypanosome
glycolysis
inhibitors
<i>Trypanosoma brucei</i>
Accès en ligne:https://www.mdpi.com/2076-0817/12/11/1290
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