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CAR-T Cells Targeting Epstein-Barr Virus gp350 Validated in a Humanized Mouse Model of EBV Infection and Lymphoproliferative Disease

Epstein-Barr virus (EBV) is a latent and oncogenic human herpesvirus. Lytic viral protein expression plays an important role in EBV-associated malignancies. The EBV envelope glycoprotein 350 (gp350) is expressed abundantly during EBV lytic reactivation and sporadically on the surface of latently inf...

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Principais autores: Constanze Slabik, Maja Kalbarczyk, Simon Danisch, Reinhard Zeidler, Frank Klawonn, Valery Volk, Nicole Krönke, Friedrich Feuerhake, Constanca Ferreira de Figueiredo, Rainer Blasczyk, Henning Olbrich, Sebastian J. Theobald, Andreas Schneider, Arnold Ganser, Constantin von Kaisenberg, Stefan Lienenklaus, Andre Bleich, Wolfgang Hammerschmidt, Renata Stripecke
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-09-01
coleção:Molecular Therapy: Oncolytics
Assuntos:
CAR-T cells
EBV
lymphoma
transplantation
PTLD
humanized mice
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2372770520301224
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