Cargo receptor Surf4 regulates endoplasmic reticulum export of proinsulin in pancreatic β-cells
Surf4 is an ER cargo receptor for proinsulin, facilitating proinsulin export out of the ERES in a cellular model of pancreatic β-cells, with its expression dependent on glucose concentration and Surf4 knockdown impairing insulin secretion.
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Portfolio
2022-05-01
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| Edice: | Communications Biology |
| On-line přístup: | https://doi.org/10.1038/s42003-022-03417-6 |
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