Surface charge of the C-terminal helix is crucial for antibacterial activity of endolysin against Gram-negative bacteria

Abstract Backgrounds Endolysins are promising alternatives to antibiotics because they can lyse bacterial cells rapidly with a low risk of resistance development, however, their effectiveness against Gram-negative bacteria is hindered by the presence of the outer membrane present in Gram-negative ba...

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Prif Awduron:	Joonbeom Kim, Su Min Son, Eunbyeol Ahn, Haejoon Park, Sangryeol Ryu
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-03-01
Cyfres:	Journal of Biomedical Science
Pynciau:	Antibiotic-resistance Gram-negative bacteria Endolysin C-terminal amphipathic helix Positive surface-charge
Mynediad Ar-lein:	https://doi.org/10.1186/s12929-025-01133-x
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