Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa

Abstract Background Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of what is known about cancer genetics co...

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Autors principals:	Michelle S. Kim, Daphne Naidoo, Ujani Hazra, Melanie H. Quiver, Wenlong C. Chen, Corinne N. Simonti, Paidamoyo Kachambwa, Maxine Harlemon, Ilir Agalliu, Shakuntala Baichoo, Pedro Fernandez, Ann W. Hsing, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Halimatou Diop, Medina Ndoye, Nana Yaa Snyper, Ben Adusei, James E. Mensah, Afua O. D. Abrahams, Richard Biritwum, Andrew A. Adjei, Akindele O. Adebiyi, Olayiwola Shittu, Olufemi Ogunbiyi, Sikiru Adebayo, Oseremen I. Aisuodionoe-Shadrach, Maxwell M. Nwegbu, Hafees O. Ajibola, Olabode P. Oluwole, Mustapha A. Jamda, Elvira Singh, Audrey Pentz, Maureen Joffe, Burcu F. Darst, David V. Conti, Christopher A. Haiman, Petrus V. Spies, André van der Merwe, Thomas E. Rohan, Judith Jacobson, Alfred I. Neugut, Jo McBride, Caroline Andrews, Lindsay N. Petersen, Timothy R. Rebbeck, Joseph Lachance
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2022-09-01
Col·lecció:	Genome Biology
Matèries:	Africa Health disparities Genomic medicine Polygenic risk scores Population genetics Prostate cancer
Accés en línia:	https://doi.org/10.1186/s13059-022-02766-z
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