Perinatal methimazole exposure impairs the distribution and function of layer 5 neurons in the mouse auditory cortex

Abstract Methimazole (MMI) is an antithyroid drug often prescribed for hyperthyroid conditions. While perinatal MMI exposure is used to model hypothyroidism in rodents, resulting in auditory cortex malformation, mice are reportedly less effective in lowering serum thyroxine levels. This raises the q...

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Váldodahkkit:	Minzi Chang, Makoto Nakanishi, Takahiro Nagayama, Hironobu Sanemori, Kohichi Ikeda, Hyeryun Shin, Hideki D. Kawai
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Nature Portfolio 2025-08-01
Ráidu:	Scientific Reports
Fáttát:	Auditory cortex Cortical development Dendritic spines Hypothyroidism Neuronal excitability Thyroid
Liŋkkat:	https://doi.org/10.1038/s41598-025-17482-4
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