The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy

Epilepsy is a neurological disorder characterized by a hyperexcitable brain tissue and unpredictable seizures, i.e., aberrant firing discharges in large neuronal populations. It is well established that proinflammatory cytokines, in addition to their canonical involvement in the immune response, hav...

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Detalhes bibliográficos

Principais autores:	Angela eChiavegato, Gabriele eLosi, Emanuele eZurolo, Eleonora eAronica, Giorgio eCarmignoto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2014-06-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	Astrocytes Calcium Seizures Epileptogenesis proinflammatory cytokines
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00155/full
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