The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model

IntroductionAlzheimer’s disease (AD) prevalence and severity are associated with increased age, female sex, and apolipoprotein E4 (APOE4) genotype. Although estrogen therapy (ET) effectively reduces symptoms of menopause including hot flashes and anxiety, and can reduce dementia risk, it is associat...

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Bibliografski detalji

Glavni autori:	M. R. Schwabe, A. W. Fleischer, R. K. Kuehn, S. Chaudhury, J. M. York, D. S. Sem, W. A. Donaldson, M. J. LaDu, K. M. Frick
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2024-11-01
Serija:	Frontiers in Aging Neuroscience
Teme:	estrogen receptor beta (ERβ) apolipoprotein E object recognition object placement hot flash Alzheimer’s disease
Online pristup:	https://www.frontiersin.org/articles/10.3389/fnagi.2024.1477045/full
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