PNMA1 is a novel immune modulator and therapeutic target in hepatocellular carcinoma linked to bile acid metabolism

Abstract Hepatocellular carcinoma (HCC) necessitates innovative prognostic biomarkers and therapeutic targets. By investigating PNMA1 in HCC via the TCGA and GEO databases and our clinical data, we found that its overexpression is associated with worse survival. The relevance of PNMA1 extends to imm...

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Bibliografische Detailangaben

Hauptverfasser:	Hongyu Chu, Yuezhan Shan, Chengwei Jiang, Yumin Zhong, Zijing Liu, Xuedong Fang, Zhaoying Yang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-01-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Hepatocellular carcinoma Proteomics Prognostic biomarkers Therapeutic target Bioinformatics analysis
Online-Zugang:	https://doi.org/10.1038/s41598-024-84368-2
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