Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease

The prevalence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. Gaining control over disease-related events in non-alcoholic steatohepatitis (NASH), an advanced form of NAFLD, is currently an unmet medical need. Hepatic fibrosis is a critical prognostic factor in NAFLD/NASH. Ther...

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Auteurs principaux:	Takefumi Kimura, Simran Singh, Naoki Tanaka, Takeji Umemura
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2021-12-01
Collection:	Frontiers in Endocrinology
Sujets:	hepatic stellate cells (HSC) GPCR (G protein coupled receptor) NAFLD (non-alcoholic fatty liver disease) non-alcoholic steatohepatitis (NASH) liver fibrosis
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fendo.2021.773432/full
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