PAFAH2 deficiency drives sepsis-induced vascular leakage by promoting ECHS1-mediated suppression of protein crotonylation and mitochondrial dysfunction

Abstract Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The vascular endothelial cells (VECs) play a pivotal role in the progression of sepsis-induced vascular leakage. While therapeutic strategies targeting pathogen elimination and inf...

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Detaylı Bibliyografya

Asıl Yazarlar:	Ruibo Yang, Yuxi Zhang, Yinyu Wu, Weichao Li, Yue Zhang, Daiqin Bao, Xiaoli Ran, Jun Zhang, Yunqin Ren, Han She, Deyu Zuo, Yaling Wang, Yi Hu, Qingxiang Mao
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	BMC 2026-05-01
Seri Bilgileri:	Inflammation and Regeneration
Konular:	Sepsis Vascular endothelial barrier function Crotonylation PAFAH2 ECHS1
Online Erişim:	https://doi.org/10.1186/s41232-026-00424-6
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