Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking. Notably, cerebellar microglial activation appears to be a common feature in different types of ataxic patients and rode...

Descripció completa

Dades bibliogràfiques

Autors principals:	Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zhu
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-05-01
Col·lecció:	Pharmacological Research
Matèries:	Cerebellum Microglia Chemogenetic manipulation Purkinje cell Ataxia
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1043661823001299
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!