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A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency

ABSTRACT To identify novel host factors as putative targets to reverse HIV-1 latency, we performed an insertional mutagenesis genetic screen in a latent HIV-1 infected pseudohaploid KBM7 cell line (Hap-Lat). Following mutagenesis, insertions were mapped to the genome, and bioinformatic analysis resu...

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Principais autores: Michael Röling, Mahsa Mollapour Sisakht, Enrico Ne, Panagiotis Moulos, Raquel Crespo, Mateusz Stoszko, Elisa De Crignis, Helen Bodmer, Tsung Wai Kan, Maryam Akbarzadeh, Vaggelis Harokopos, Pantelis Hatzis, Robert-Jan Palstra, Tokameh Mahmoudi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021-12-01
coleção:mBio
Assuntos:
latency
haploid forward genetic screen
host factor
human immunodeficiency virus
Acesso em linha:https://journals.asm.org/doi/10.1128/mBio.02980-21
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