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Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Abstract Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, the role of histone lactylation in tumorigenesis remains unclear. Results Here, we show histone lactylati...

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主要な著者: Jie Yu, Peiwei Chai, Minyue Xie, Shengfang Ge, Jing Ruan, Xianqun Fan, Renbing Jia
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2021-03-01
シリーズ:Genome Biology
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オンライン・アクセス:https://doi.org/10.1186/s13059-021-02308-z
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