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Crystal structure of apo human spermidine synthase reveals dynamic rearrangement at the active site

Polyamines are polycations involved in both differentiation and proliferation of cells. Highly conserved polyamine biosynthetic enzymes are involved in the synthesis of polyamines. Spermidine synthase (SPDS) is an important enzyme in the polyamine biosynthetic pathway, and it is an aminopropyl-trans...

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Principais autores: Omowumi O. Fagbohun, Molly A. Canfield, Jonathan A. Clinger
Formato: Artigo
Idioma:Inglês
Publicado em: AIP Publishing LLC and ACA 2026-01-01
coleção:Structural Dynamics
Acesso em linha:https://pubs.aip.org/aca/sdy/article-pdf/doi/10.1063/4.0001199/20873828/014701_1_4.0001199.pdf
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