MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer

Abstract Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new therapies, however, few mouse models represent the complexity of TNBC. Here, we develop a female TNBC murine model by mimicking two common...

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Detalhes bibliográficos

Principais autores:	Zinab O. Doha, Xiaoyan Wang, Nicholas L. Calistri, Jennifer Eng, Colin J. Daniel, Luke Ternes, Eun Na Kim, Carl Pelz, Michael Munks, Courtney Betts, Sunjong Kwon, Elmar Bucher, Xi Li, Trent Waugh, Zuzana Tatarova, Dylan Blumberg, Aaron Ko, Nell Kirchberger, Jennifer A. Pietenpol, Melinda E. Sanders, Ellen M. Langer, Mu-Shui Dai, Gordon Mills, Koei Chin, Young Hwan Chang, Lisa M. Coussens, Joe W. Gray, Laura M. Heiser, Rosalie C. Sears
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-09-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-023-40841-6
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