Aberrant DNA methylation within circadian entrainment and clock genes two years after pediatric critical illness is associated with impaired physical and neurocognitive development

Abstract Background Pediatric critical illness can disrupt circadian rhythms, potentially leading to long-term deficits in growth, neurocognition, and behavior. Disturbances in circadian rhythms have been associated with altered gene expression and DNA methylation. We investigated long-term DNA meth...

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Hauptverfasser:	Grégoire Coppens, Arnout B. G. Cramer, Ilse Vanhorebeek, Fabian Güiza, Pieter J. Wouters, Inês Chaves, Matthijs de Hoog, Karolijn Dulfer, Koen F. M. Joosten, Greet Van den Berghe, Sascha C. A. T. Verbruggen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Clinical Epigenetics
Schlagworte:	Critical illness Children PICU DNA methylation Epigenetics Circadian rhythm
Online-Zugang:	https://doi.org/10.1186/s13148-025-02027-3
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