NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells. Noncancerous cells—despite high expression of these antigens—are protected from cytotoxic...

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Auteurs principaux:	Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-06-01
Collection:	iScience
Sujets:	Natural sciences Biological sciences Immunology Systems biology Cancer systems biology
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2589004224011350
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