AceE affects the optimum growth and biofilm formation of Mycobacterium tuberculosis via cell wall lipid remodeling

ABSTRACT Central carbon metabolism is fundamental to the growth and virulence of Mycobacterium tuberculosis (Mtb). The aceE gene encodes the E1 subunit of the pyruvate dehydrogenase complex that irreversibly converts pyruvate to acetyl-CoA. There, we investigated the impact of aceE inactivation on t...

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Autors principals:	Suting Chen, Jifang Zheng, Qiang Liu, Tianlu Teng, Ziyi Yang, Fengmin Huo, Yi Xue, Liang Li, Hairong Huang
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2026-05-01
Col·lecció:	mSystems
Matèries:	aceE Mycobacterium tuberculosis lipid metabolism growth pathogenicity
Accés en línia:	https://journals.asm.org/doi/10.1128/msystems.01732-25
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