Hemodynamics and matrix stiffness shape the pathogenicity of SPP1+ macrophages

BackgroundMacrophages exhibit significant plasticity and are integral to tissue homeostasis and disease progression. Recent single-cell RNA sequencing (scRNA-seq) analyses identify secreted phosphoprotein 1-positive (SPP1+) macrophages as a highly conserved pathogenic subpopulation. This subset pred...

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Hlavní autoři:	Hongjiu Zhang, Jiang Han, Shirong Zhu, Manhong Yi, Keyi Fan, Runze Chang, Yongbin Shi, Honglin Dong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-05-01
Edice:	Frontiers in Immunology
Témata:	atherosclerosis extracellular matrix remodeling mechanobiology SPP1+ macrophages YAP/TAZ
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1856522/full
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