SCRABBLE: single-cell RNA-seq imputation constrained by bulk RNA-seq data
Abstract Single-cell RNA-seq data contain a large proportion of zeros for expressed genes. Such dropout events present a fundamental challenge for various types of data analyses. Here, we describe the SCRABBLE algorithm to address this problem. SCRABBLE leverages bulk data as a constraint and reduce...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2019-05-01
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| Serie: | Genome Biology |
| Soggetti: | |
| Accesso online: | http://link.springer.com/article/10.1186/s13059-019-1681-8 |
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