Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration

High doses of acetaminophen (APAP) result in hepatotoxicity that involves metabolic activation of the parent compound, covalent binding of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) to liver proteins, and depletion of hepatic glutathione. Impaired fatty acid β-oxidation has been...

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Váldodahkkit:	Jack Hinson, Laura James, Pippa Simpson, Leah Hennings, Ke Yan, Sandra McCullough, Shubhra Chaudhuri, Richard Beger, Lisa Pence, Sudeepa Bhattacharyya
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2013-08-01
Ráidu:	Metabolites
Fáttát:	acetaminophen hepatic β-oxidation toxicity acylcarnitine
Liŋkkat:	http://www.mdpi.com/2218-1989/3/3/606
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