Synthesized flavanoid-derived ligand reduced dengue virus type-2 replication in vitro

Objective: To investigate the antiviral property of a lead ligand, YK51 that was synthesized based on the flavanoid of a natural product toward dengue virus type-2 (DENV2) replication. Methods: cRNA was isolated from HepG2 cells inoculated with 1000 median tissue culture infective dose of DENV2 and...

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Autors principals:	Mudiana Muhamad, Yean Kee Lee, Noorsaadah Abd. Rahman, Rohana Yusof
Format:	Artigo
Idioma:	Inglês
Publicat:	Wolters Kluwer Medknow Publications 2017-02-01
Col·lecció:	Asian Pacific Journal of Tropical Biomedicine
Matèries:	Synthesized derived ligand Dengue replication Inhibition assay Quantitative RT-PCR Cytoskeletal actin tubulin distribution
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2221169116310917
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