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RNA-based translation activators for targeted gene upregulation

Abstract Technologies capable of programmable translation activation offer strategies to develop therapeutics for diseases caused by insufficient gene expression. Here, we present “translation-activating RNAs” (taRNAs), a bifunctional RNA-based molecular technology that binds to a specific mRNA of i...

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I tiakina i:
Ngā kaituhi matua: Yang Cao, Huachun Liu, Shannon S. Lu, Krysten A. Jones, Anitha P. Govind, Okunola Jeyifous, Christine Q. Simmons, Negar Tabatabaei, William N. Green, Jimmy. L. Holder, Soroush Tahmasebi, Alfred L. George, Bryan C. Dickinson
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2023-10-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-023-42252-z
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