An iPSC-derived neuronal model reveals manganese’s role in neuronal endocytosis, calcium flux and mitochondrial bioenergetics

Summary: Manganese (Mn) is an essential trace metal required for normal biological function, yet it also poses neurotoxic risks when dysregulated. Maintaining proper intracellular and extracellular Mn levels is critical, as Mn imbalance has been implicated in a spectrum of human diseases—including i...

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Principais autores:	Dimitri Budinger, Sharmin Alhaque, Ramón González-Méndez, Chris Dadswell, Katy Barwick, Arianna Ferrini, Charlotte Roth, Conor J. McCann, Karin Tuschl, Fatma Al Jasmi, Maha S. Zaki, Julien H. Park, Russell C. Dale, Shekeeb Mohammad, John Christodoulou, Dale Moulding, Michael R. Duchen, Serena Barral, Manju A. Kurian
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2025-09-01
סדרה:	iScience
נושאים:	Molecular biology Neuroscience Cell biology
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S258900422501572X
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