Metabolic changes in normal-appearing white matter associate with MRI measures of disease burden in relapsing-remitting multiple sclerosis over three years

Abstract Myo-inositol (mI) and total N-acetylaspartate (tNAA) are potential MR spectroscopic imaging (MRSI) biomarkers of smouldering-associated worsening in multiple sclerosis (MS). In this study, we explored metabolic changes in normal-appearing white matter (NAWM) in patients with relapsing–remit...

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Detalhes bibliográficos

Principais autores:	Anna Zöchner, Wolfgang Bogner, Assunta Dal-Bianco, Bernhard Strasser, Gilbert Hangel, Paulus Stefan Rommer, Eva Niess
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Scientific Reports
Assuntos:	MRSI Normal-appearing white matter Paramagnetic rim lesions Myo-inositol N-acetylaspartate Multiple sclerosis
Acesso em linha:	https://doi.org/10.1038/s41598-026-45342-2
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