Munc18-1 catalyzes neuronal SNARE assembly by templating SNARE association

Sec1/Munc18-family (SM) proteins are required for SNARE-mediated membrane fusion, but their mechanism(s) of action remain controversial. Using single-molecule force spectroscopy, we found that the SM protein Munc18-1 catalyzes step-wise zippering of three synaptic SNAREs (syntaxin, VAMP2, and SNAP-2...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Junyi Jiao, Mengze He, Sarah A Port, Richard W Baker, Yonggang Xu, Hong Qu, Yujian Xiong, Yukun Wang, Huaizhou Jin, Travis J Eisemann, Frederick M Hughson, Yongli Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2018-12-01
coleção:	eLife
Assuntos:	Sec1/Munc18 (SM) proteins SNARE proteins SNARE assembly optical tweezers template complex membrane fusion
Acesso em linha:	https://elifesciences.org/articles/41771
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!