Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors

Some (<i>E</i>)-3-(3-(4-(benzyloxy)phenyl)-1-phenyl-1<i>H</i>-pyrazol-4-yl)-1-phenylprop-2-en-1-one conjugates <b>5a</b>–<b>r</b> were designed; synthesized; characterized by ¹H, ¹³C NMR, and ESI-MS; and evaluated for tubulin polymerization inhibitory activity and in vitro cyto...

Volledige beschrijving

Bibliografische gegevens

Hoofdauteurs:	Md. Jahangir Alam, Ozair Alam, Ahmad Perwez, Moshahid Alam Rizvi, Mohd Javed Naim, Vegi G. M. Naidu, Mohd Imran, Mohammed M. Ghoneim, Sultan Alshehri, Faiyaz Shakeel
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	MDPI AG 2022-02-01
Reeks:	Pharmaceuticals
Onderwerpen:	pyrazole conjugate anticancer MTT assay molecular docking cytotoxicity tubulin polymerization inhibitors
Online toegang:	https://www.mdpi.com/1424-8247/15/3/280
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!