Identifying pathogenicity of human variants via paralog-based yeast complementation.
To better understand the health implications of personal genomes, we now face a largely unmet challenge to identify functional variants within disease-associated genes. Functional variants can be identified by trans-species complementation, e.g., by failure to rescue a yeast strain bearing a mutatio...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2017-05-01
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| Serie: | PLoS Genetics |
| Accesso online: | https://doi.org/10.1371/journal.pgen.1006779 |
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