Cancer-secreted exosomal miR-1246 promotes colorectal cancer liver metastasis by activating hepatic stellate cells

Abstract Colorectal cancer liver metastases (CRLM) are the primary cause of mortality in colorectal cancer (CRC) patients, highlighting the importance of understanding the underlying mechanisms. The tumor microenvironment (TME) and its interaction with tumor cells play a crucial role in CRLM progres...

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Autors principals:	Xiaolong Liu, Jialong Liu, Xuanyin Wang, Yang Zou, Xinyi Tao, Jingyu Li, Mengnan Ye, Wanbei Xu, Yunyao Deng, Lixin Liu, Jingbo Sun, Qingling Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-02-01
Col·lecció:	Molecular Medicine
Matèries:	CRLM Exosome miR-1246 HSCs Cholesterol metabolism
Accés en línia:	https://doi.org/10.1186/s10020-025-01112-w
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