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Early cerebrospinal fluid elevations of pTau-217 in severe traumatic brain injury subjects

IntroductionTauopathies, including Alzheimer’s disease (AD), feature abnormal accumulations of hyperphosphorylated Tau protein; however, their biomarker potential in traumatic brain injury (TBI) is not well-defined. This study investigated whether cerebrospinal fluid (CSF) phosphorylated Tau at thre...

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Principais autores: Hamad Yadikar, Firas H. Kobeissy, Claudia Robertson, Spyridoula Tsetsou, John B. Williamson, Damon G. Lamb, Amy K. Wagner, Todd Kibaugh, Shih-Han Kao, Zhifeng Kou, Robert D. Welch, Jose-Miguel Yamal, Luis Leon-Novelo, Richard Rubenstein, Kevin K. W. Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-07-01
Serier:Frontiers in Neurology
Fag:
traumatic brain injury
CSF biomarkers
pTau-217
neurotrauma prognostics
diagnostic biomarkers
Online adgang:https://www.frontiersin.org/articles/10.3389/fneur.2025.1632679/full
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