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Broadening anticancer spectrum by preprocessing and treatment of T- lymphocytes expressed FcγRI and monoclonal antibodies for refractory cancers

BackgroundChimeric antigen receptor T (CAR-T) cell therapies have achieved remarkable success in the treatment of hematological tumors. However, given the distinct features of solid tumors, particularly heterogeneity, metabolic aggressiveness, and fewer immune cells in tumor microenvironment (TME),...

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Principais autores: Lei Tang, Qinyi Sun, Mengyuan Li, Xiaoxiao Yu, Jinguo Meng, Yun Zhang, Yuxiao Ma, Aizhong Zeng, Zhuolan Li, Yuanyuan Liu, Xinyu Xu, Wei Guo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-06-01
Serier:Frontiers in Immunology
Fag:
CAR-T
monoclonal antibodies
FcγRI
ADCC
solid tumors
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1400177/full
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