Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

Alzheimer’s disease (AD) has no cure. Earlier, we showed that partial inhibition of mitochondrial complex I (MCI) with the small molecule CP2 induces an adaptive stress response, activating multiple neuroprotective mechanisms. Chronic treatment reduced inflammation, Aβ and pTau accumulation, improve...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Jessica Panes, Thi Kim Oanh Nguyen, Huanyao Gao, Trace A. Christensen, Andrea Stojakovic, Sergey Trushin, Jeffrey L. Salisbury, Jorge Fuentealba, Eugenia Trushina
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	MDPI AG 2023-04-01
סדרה:	Cells
נושאים:	Alzheimer’s disease (AD) mitochondria endoplasmic reticulum (ER) serial block-face scanning electron microscopy (SBFSEM) three-dimensional electron microscopy (3DEM) small molecule mitochondria targeted therapeutics
גישה מקוונת:	https://www.mdpi.com/2073-4409/12/8/1111
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!