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KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats

Objective: Dual amylin and calcitonin receptor agonists (DACRAs) are novel therapeutic agents that not only improve insulin sensitivity but also work as an adjunct to established T2DM therapies. DACRAs are currently administered once daily, though it is unknown whether DACRAs with increased plasma h...

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Principais autores: K.V. Andreassen, A.T. Larsen, N. Sonne, K.E. Mohamed, M.A. Karsdal, K. Henriksen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021-11-01
Serier:Molecular Metabolism
Fag:
DACRA
Once-weekly
T2DM
Obesity
HFD rats
ZDF rats
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877821001277
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