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Lactate and gastric cancer immunotherapy from regulatory mechanisms to therapeutic strategies: a critical review

Abstract Background Gastric cancer (GC) remains a leading cause of cancer-related mortality globally, with current immunotherapies exhibiting limited therapeutic efficacy owing to the immunosuppressive tumour microenvironment (TME). Main body Lactate, a hallmark metabolic by-product of tumour glycol...

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Principais autores: Yuanzhu Hao, Yanan Zhang, Yu Zhang, Duo Yang, Dan Ren, Yixing Yue, Qian Li, QingLing Fan, Chao Sun, Manli Cui, Mingxin Zhang
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2025-11-01
סדרה:European Journal of Medical Research
נושאים:
Gastric cancer
Lactate metabolism
Tumour microenvironment
Immunotherapy
Lactylation
Immune evasion
גישה מקוונת:https://doi.org/10.1186/s40001-025-03383-9
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