Alternative Polyadenylation Signatures Distinguish Maladaptive Right Ventricular Remodeling in Pulmonary Hypertension: Implications for RNA-Based Diagnostics and Therapeutics

Increased pulmonary vascular pressures due to vascular remodeling, elevated vascular resistance, and vasoconstriction characterize Pulmonary Arterial Hypertension (PAH). The narrowing of the pulmonary arteries and obstruction of blood flow increase the Right Ventricular (RV) afterload, forcing the R...

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Autores principales:	Janani Subramaniam, Venkata Jonnakuti, Scott D. Collum, Sandra Martineau, Kai-Lieh Huang, Sandra Breuils-Bonnet, Andrea L. Frump, Bindu H. Akkanti, Jayeshkumar A. Patel, Manish K. Patel, Ismael Salas de Armas, Isabella N. Lefebvre, Rajko Radovancevic, Elvin Blanco, Eric J. Wagner, Igor Gregoric, Sriram Nathan, Biswajit Kar, Steeve Provencher, Sebastien Bonnet, François Potus, Hari Krishna Yalamanchili, Harry Karmouty-Quintana
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-02-01
Colección:	British Journal of Biomedical Science
Materias:	3’UTR shortening CPSF5 decompensated RV right heart failure right ventricle
Acceso en línea:	https://www.frontierspartnerships.org/articles/10.3389/bjbs.2026.15687/full
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