Proton pump inhibitors enhance macropinocytosis‐mediated extracellular vesicle endocytosis by inducing membrane v‐ATPase assembly

Abstract Besides participating in diverse pathological and physiological processes, extracellular vesicles (EVs) are also excellent drug‐delivery vehicles. However, clinical drugs modulating EV levels are still lacking. Here, we show that proton pump inhibitors (PPIs) reduce EVs by enhancing macropi...

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Bibliographic Details

Main Authors:	Xinliang Lu, Zhengbo Song, Jiayue Hao, Xianghui Kong, Weiyi Yuan, Yingying Shen, Chengyan Zhang, Jie Yang, Pengfei Yu, Yun Qian, Gensheng Zhang, Huajun Feng, Jianli Wang, Zhenzhai Cai, Zhijian Cai
Format:	Artigo
Language:	Inglês
Published:	Wiley 2024-04-01
Series:	Journal of Extracellular Vesicles
Subjects:	extracellular vesicles macropinocytosis pH proton pump inhibitors v‐ATPases
Online Access:	https://doi.org/10.1002/jev2.12426
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