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Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model

A potent effector of innate immunity, the complement system contributes significantly to the pathophysiology of traumatic brain injury (TBI). This study investigated the role of the complement cascade in neurobehavioral outcomes and neuropathology after TBI. Agents acting at different levels of the...

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Principais autores: Min Chen, Stephen R. Edwards, Dhiraj Maskey, Trent M. Woodruff, Stephen Tomlinson, David Reutens
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publishing 2023-10-01
coleção:Neurotrauma Reports
Assuntos:
C1-Inh
C5 deficiency
complement system
CR2-Crry
PMX205
traumatic brain injury
Acesso em linha:https://www.liebertpub.com/doi/full/10.1089/NEUR.2023.0024
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