Gene set enrichment analysis of curated monogenic loci highlights key pathways and multisystem involvement in male infertility

Abstract Background Male infertility affects approximately 10% of men globally, yet approximately 70% of cases lack a definitive genetic diagnosis. Next-generation sequencing has identified numerous monogenic causes, many of which are linked to broader systemic conditions. We curated a list of 596 c...

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Detalhes bibliográficos

Principais autores:	Matthew Yang, Katreya Lovrenert, Nannan Thirumavalavan, Michael L. Eisenberg, Fredrick R. Schumacher, Chen-Han Wilfred Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-06-01
coleção:	Basic and Clinical Andrology
Assuntos:	Male infertility Genetics Gene set enrichment analysis Gene ontology Overall health
Acesso em linha:	https://doi.org/10.1186/s12610-026-00316-2
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