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Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Abstract G protein‐coupled receptors (GPCRs) are the most common and important drug targets. However, >70% of GPCRs are undruggable or difficult to target using conventional chemical agonists/antagonists. Small nucleic acid molecules, which can sequence‐specifically modulate any gene, offer a unique...

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Principais autores: Yunfang Xiong, Ran Ke, Qingyu Zhang, Wenjun Lan, Wanjun Yuan, Karol Nga Ieng Chan, Tom Roussel, Yifan Jiang, Jing Wu, Shuai Liu, Alice Sze Tsai Wong, Joong Sup Shim, Xuanjun Zhang, Ruiyu Xie, Nelson Dusetti, Juan Iovanna, Nagy Habib, Ling Peng, Leo Tsz On Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley 2022-09-01
Colecção:Advanced Science
Assuntos:
cancer therapies
dendrimer vectors
G protein‐coupled receptors
Mas receptors (MAS1s)
small activating RNA
Acesso em linha:https://doi.org/10.1002/advs.202200562
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