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HIGD2A silencing impairs hepatocellular carcinoma growth via inhibiting mitochondrial function and the MAPK/ERK pathway

Abstract Background The Hypoxia inducible gene domain family member 2A (HIGD2A) protein is indispensable for the assembly of the mitochondrial respiratory supercomplex, which has been implicated in cell proliferation and cell survival under hypoxic conditions. Because the liver has a naturally low o...

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Principais autores: Kuiyuan Huang, Ziying Liu, Zhanglian Xie, Xiaoran Li, Haixing Zhang, Yu Chen, Yiran Wang, Zimo Lin, Chuanjiang Li, Hongyan Liu, Xiaoyong Zhang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-04-01
Serier:Journal of Translational Medicine
Fag:
Hepatocellular carcinoma
HIGD2A
Mitochondria
ATP
The MAPK/ERK pathway
Online adgang:https://doi.org/10.1186/s12967-023-04105-7
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