Transient adenovirus-Cre infection causes long-lasting remodeling of the mammary gland immune landscape

Abstract Understanding how immune cells respond to early oncogenic events is essential for designing immune-based strategies to intercept breast cancer. Mouse models that induce mammary tumorigenesis through Cre-mediated genetic manipulations can be used to study these early events. However, the imm...

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Detalhes bibliográficos

Principais autores:	Sen Han, Dongyi Zhao, Xueqing Chen, Miao Zhu, Tiantian Li, Chujun Wang, Huabiao Chen, Zhe Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-03-01
coleção:	Scientific Reports
Assuntos:	Adenovirus-Cre Mammary gland immune microenvironment Breast cancer mouse model p53-loss CD8+ tissue-resident T cells Premalignancy
Acesso em linha:	https://doi.org/10.1038/s41598-026-43069-8
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